| Week | Player | Team | Pos | Pts |
| Jimmy Smith | JAX | WR | 47 | |
| Rich Gannon | OAK | QB | 31 | |
| Steve Beurlein | CAR | QB | 27 | |
| Peyton Manning | IND | QB | 26 | |
| Tony Banks | BAL | QB | 26 | |
| Mark Brunell | JAX | QB | 25 | |
| Edgerrin James | IND | RB | 24 | |
| Rob Johnson | BUF | QB | 24 | |
| Kurt Warner | STL | QB | 23 | |
| Vinny Testeverde | NYJ | QB | 23 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Jimmy Smith | JAX | WR | 58 | |
| Edgerrin James | IND | RB | 52 | |
| Brian Griese | DEN | QB | 51 | |
| Daunte Culpepper | MIN | QB | 51 | |
| Marshall Faulk | STL | RB | 49 | |
| Kurt Warner | STL | QB | 48 | |
| Rich Gannon | OAK | QB | 43 | |
| Mark Brunell | JAX | QB | 43 | |
| Peyton Manning | IND | QB | 42 | |
| Steve Beurlein | CAR | QB | 40 |