| Week | Player | Team | Pos | Pts |
| Marshall Faulk | STL | RB | 37 | |
| Stephen Davis | WAS | RB | 26 | |
| Isaac Bruce | STL | WR | 24 | |
| Kurt Warner | STL | QB | 22 | |
| Lamar Smith | MIA | RB | 22 | |
| Rob Johnson | BUF | QB | 21 | |
| Jeff Garcia | SF | QB | 21 | |
| Tim Brown | OAK | WR | 21 | |
| Daunte Culpepper | MIN | QB | 19 | |
| Jerome Bettis | PIT | RB | 19 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Marshall Faulk | STL | RB | 86 | |
| Kurt Warner | STL | QB | 70 | |
| Daunte Culpepper | MIN | QB | 70 | |
| Brian Griese | DEN | QB | 67 | |
| Jimmy Smith | JAX | WR | 62 | |
| Rob Johnson | BUF | QB | 59 | |
| Mark Brunell | JAX | QB | 56 | |
| Stephen Davis | WAS | RB | 55 | |
| Rich Gannon | OAK | QB | 54 | |
| Steve Beurlein | CAR | QB | 53 |