| Week | Player | Team | Pos | Pts |
| Peyton Manning | IND | QB | 34 | |
| Torry Holt | STL | WR | 30 | |
| Charlie Garner | SF | RB | 29 | |
| Kurt Warner | STL | QB | 28 | |
| Jimmy Smith | JAX | WR | 25 | |
| Jeff Garcia | SF | QB | 24 | |
| Isaac Bruce | STL | WR | 21 | |
| Edgerrin James | IND | RB | 20 | |
| Curtis Martin | NYJ | RB | 20 | |
| Brad Johnson | WAS | QB | 20 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Kurt Warner | STL | QB | 98 | |
| Marshall Faulk | STL | RB | 94 | |
| Jimmy Smith | JAX | WR | 87 | |
| Peyton Manning | IND | QB | 76 | |
| Mark Brunell | JAX | QB | 73 | |
| Edgerrin James | IND | RB | 72 | |
| Daunte Culpepper | MIN | QB | 70 | |
| Curtis Martin | NYJ | RB | 68 | |
| Brian Griese | DEN | QB | 67 | |
| Charlie Garner | SF | RB | 66 |