| Week | Player | Team | Pos | Pts |
| Randy Moss | MIN | WR | 34 | |
| Kurt Warner | STL | QB | 31 | |
| Marshall Faulk | STL | RB | 28 | |
| Isaac Bruce | STL | WR | 28 | |
| Brett Favre | GB | QB | 25 | |
| Drew Bledsoe | NE | QB | 25 | |
| Steve McNair | TEN | QB | 25 | |
| Daunte Culpepper | MIN | QB | 24 | |
| Brian Griese | DEN | QB | 24 | |
| Marcus Robinson | CHI | WR | 24 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Kurt Warner | STL | QB | 129 | |
| Marshall Faulk | STL | RB | 122 | |
| Daunte Culpepper | MIN | QB | 94 | |
| Peyton Manning | IND | QB | 93 | |
| Brian Griese | DEN | QB | 91 | |
| Jimmy Smith | JAX | WR | 89 | |
| Isaac Bruce | STL | WR | 88 | |
| Charlie Garner | SF | RB | 86 | |
| Edgerrin James | IND | RB | 84 | |
| Stephen Davis | WAS | RB | 83 |