| Week | Player | Team | Pos | Pts |
| Edgerrin James | IND | RB | 39 | |
| Marshall Faulk | STL | RB | 37 | |
| Curtis Martin | NYJ | RB | 33 | |
| Ricky Williams | NO | RB | 30 | |
| Rod Smith | DEN | WR | 29 | |
| Jeff Garcia | SF | QB | 28 | |
| Eddie George | TEN | RB | 26 | |
| Brian Griese | DEN | QB | 26 | |
| Kurt Warner | STL | QB | 25 | |
| Charlie Garner | SF | RB | 23 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Marshall Faulk | STL | RB | 159 | |
| Kurt Warner | STL | QB | 154 | |
| Daunte Culpepper | MIN | QB | 139 | |
| Brian Griese | DEN | QB | 137 | |
| Edgerrin James | IND | RB | 133 | |
| Jeff Garcia | SF | QB | 129 | |
| Charlie Garner | SF | RB | 127 | |
| Peyton Manning | IND | QB | 123 | |
| Rich Gannon | OAK | QB | 120 | |
| Stephen Davis | WAS | RB | 115 |