| Week | Player | Team | Pos | Pts |
| Corey Dillon | CIN | RB | 39 | |
| Albert Connell | WAS | WR | 39 | |
| Ricky Williams | NO | RB | 36 | |
| James Stewart | DET | RB | 31 | |
| Marvin Harrison | IND | WR | 27 | |
| Lamar Smith | MIA | RB | 27 | |
| Brian Griese | DEN | QB | 25 | |
| Tim Biakabatuka | CAR | RB | 24 | |
| Steve Beurlein | CAR | QB | 24 | |
| Isaac Bruce | STL | WR | 24 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Marshall Faulk | STL | RB | 174 | |
| Daunte Culpepper | MIN | QB | 163 | |
| Kurt Warner | STL | QB | 163 | |
| Brian Griese | DEN | QB | 162 | |
| Edgerrin James | IND | RB | 157 | |
| Jeff Garcia | SF | QB | 151 | |
| Charlie Garner | SF | RB | 146 | |
| Peyton Manning | IND | QB | 145 | |
| Ricky Williams | NO | RB | 140 | |
| Stephen Davis | WAS | RB | 138 |