| Week | Player | Team | Pos | Pts |
| Marshall Faulk | STL | RB | 38 | |
| Shaun King | TB | QB | 25 | |
| Derrick Alexander | KC | WR | 25 | |
| Mark Brunell | JAX | QB | 24 | |
| Jeff Garcia | SF | QB | 23 | |
| Terrell Owens | SF | WR | 23 | |
| Edgerrin James | IND | RB | 21 | |
| Trent Green | STL | QB | 21 | |
| Peyton Manning | IND | QB | 20 | |
| Ricky Williams | NO | RB | 20 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Marshall Faulk | STL | RB | 212 | |
| Daunte Culpepper | MIN | QB | 181 | |
| Edgerrin James | IND | RB | 178 | |
| Jeff Garcia | SF | QB | 174 | |
| Peyton Manning | IND | QB | 165 | |
| Kurt Warner | STL | QB | 163 | |
| Brian Griese | DEN | QB | 162 | |
| Ricky Williams | NO | RB | 160 | |
| Charlie Garner | SF | RB | 157 | |
| Stephen Davis | WAS | RB | 150 |