| Week | Player | Team | Pos | Pts |
| Fred Taylor | JAX | RB | 48 | |
| Eddie George | TEN | RB | 32 | |
| Robert Smith | MIN | RB | 29 | |
| Gus Frerotte | DEN | QB | 29 | |
| Daunte Culpepper | MIN | QB | 26 | |
| Ed McCaffrey | DEN | WR | 26 | |
| Rob Johnson | BUF | QB | 25 | |
| Rod Smith | DEN | WR | 24 | |
| Trent Green | STL | QB | 24 | |
| Peyton Manning | IND | QB | 23 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Daunte Culpepper | MIN | QB | 254 | |
| Edgerrin James | IND | RB | 234 | |
| Jeff Garcia | SF | QB | 231 | |
| Marshall Faulk | STL | RB | 229 | |
| Peyton Manning | IND | QB | 225 | |
| Rich Gannon | OAK | QB | 213 | |
| Brian Griese | DEN | QB | 201 | |
| Charlie Garner | SF | RB | 198 | |
| Ricky Williams | NO | RB | 186 | |
| Stephen Davis | WAS | RB | 184 |