| Week | Player | Team | Pos | Pts |
| Mike Anderson | DEN | RB | 32 | |
| Jamal Lewis | BAL | RB | 29 | |
| Donovan McNabb | PHI | QB | 27 | |
| Randy Moss | MIN | WR | 26 | |
| Ricky Watters | SEA | RB | 25 | |
| Mushin Muhammed | CAR | WR | 25 | |
| Corey Dillon | CIN | RB | 24 | |
| Rich Gannon | OAK | QB | 23 | |
| Eddie George | TEN | RB | 22 | |
| Michael Pittman | AZ | RB | 22 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Daunte Culpepper | MIN | QB | 270 | |
| Edgerrin James | IND | RB | 248 | |
| Peyton Manning | IND | QB | 243 | |
| Rich Gannon | OAK | QB | 236 | |
| Marshall Faulk | STL | RB | 232 | |
| Jeff Garcia | SF | QB | 231 | |
| Brian Griese | DEN | QB | 201 | |
| Robert Smith | MIN | RB | 198 | |
| Charlie Garner | SF | RB | 198 | |
| Steve Beurlein | CAR | QB | 193 |