| Week | Player | Team | Pos | Pts |
| Mike Anderson | DEN | RB | 49 | |
| Fred Taylor | JAX | RB | 36 | |
| David Boston | AZ | WR | 30 | |
| Corey Dillon | CIN | RB | 27 | |
| Elvis Grbac | KC | QB | 27 | |
| Curtis Martin | NYJ | RB | 26 | |
| Jeff Garcia | SF | QB | 24 | |
| Robert Smith | MIN | RB | 24 | |
| Tony Gonzales | KC | TE | 20 | |
| Vinny Testeverde | NYJ | QB | 20 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Daunte Culpepper | MIN | QB | 280 | |
| Peyton Manning | IND | QB | 262 | |
| Jeff Garcia | SF | QB | 255 | |
| Rich Gannon | OAK | QB | 255 | |
| Edgerrin James | IND | RB | 255 | |
| Marshall Faulk | STL | RB | 244 | |
| Robert Smith | MIN | RB | 222 | |
| Charlie Garner | SF | RB | 207 | |
| Mark Brunell | JAX | QB | 203 | |
| Eddie George | TEN | RB | 202 |