| Week | Player | Team | Pos | Pts |
| Jeff Garcia | SF | QB | 38 | |
| Terrell Owens | SF | WR | 36 | |
| Daunte Culpepper | MIN | QB | 35 | |
| Shaun Alexander | SEA | RB | 28 | |
| Priest Holmes | KC | RB | 27 | |
| Steve McNair | TEN | QB | 26 | |
| Brett Favre | GB | QB | 25 | |
| Ricky Williams | NO | RB | 23 | |
| Brad Johnson | TB | QB | 23 | |
| Corey Dillon | CIN | RB | 21 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Daunte Culpepper | MIN | QB | 120 | |
| Jeff Garcia | SF | QB | 114 | |
| Kurt Warner | STL | QB | 107 | |
| Curtis Martin | NYJ | RB | 98 | |
| Brett Favre | GB | QB | 95 | |
| LaDainian Tomlinson | SD | RB | 95 | |
| Marshall Faulk | STL | RB | 93 | |
| Donovan McNabb | PHI | QB | 92 | |
| Terrell Owens | SF | WR | 82 | |
| Rich Gannon | OAK | QB | 82 |