| Week | Player | Team | Pos | Pts |
| Daunte Culpepper | MIN | QB | 26 | |
| Jerome Bettis | PIT | RB | 24 | |
| Doug Flutie | SD | QB | 21 | |
| Marvin Harrison | IND | WR | 21 | |
| Peyton Manning | IND | QB | 20 | |
| Trent Green | KC | QB | 19 | |
| David Boston | AZ | WR | 19 | |
| Edgerrin James | IND | RB | 17 | |
| Aaron Brooks | NO | QB | 16 | |
| Quadry Ismail | BAL | WR | 16 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Daunte Culpepper | MIN | QB | 146 | |
| Kurt Warner | STL | QB | 120 | |
| Jeff Garcia | SF | QB | 114 | |
| Brett Favre | GB | QB | 109 | |
| Donovan McNabb | PHI | QB | 106 | |
| Curtis Martin | NYJ | RB | 104 | |
| Peyton Manning | IND | QB | 101 | |
| LaDainian Tomlinson | SD | RB | 101 | |
| Marshall Faulk | STL | RB | 93 | |
| Priest Holmes | KC | RB | 91 |