| Week | Player | Team | Pos | Pts |
| Steve McNair | TEN | QB | 37 | |
| Ahman Green | GB | RB | 26 | |
| Priest Holmes | KC | RB | 24 | |
| Terrell Owens | SF | WR | 24 | |
| Rod Smith | DEN | WR | 23 | |
| Rich Gannon | OAK | QB | 23 | |
| Peyton Manning | IND | QB | 22 | |
| Stephen Davis | WAS | RB | 22 | |
| Tim Brown | OAK | WR | 22 | |
| Anthony Thomas | CHI | RB | 22 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Daunte Culpepper | MIN | QB | 162 | |
| Jeff Garcia | SF | QB | 152 | |
| Peyton Manning | IND | QB | 140 | |
| Rod Smith | DEN | WR | 134 | |
| Donovan McNabb | PHI | QB | 134 | |
| Kurt Warner | STL | QB | 133 | |
| Curtis Martin | NYJ | RB | 128 | |
| Priest Holmes | KC | RB | 122 | |
| Brian Griese | DEN | QB | 122 | |
| LaDainian Tomlinson | SD | RB | 119 |