| Week | Player | Team | Pos | Pts |
| Shaun Alexander | SEA | RB | 44 | |
| Marvin Harrison | IND | WR | 35 | |
| Marshall Faulk | STL | RB | 31 | |
| Donovan McNabb | PHI | QB | 29 | |
| Curtis Martin | NYJ | RB | 29 | |
| Duce Staley | PHI | RB | 28 | |
| Aaron Brooks | NO | QB | 25 | |
| Jeff Garcia | SF | QB | 24 | |
| Terrell Owens | SF | WR | 23 | |
| Daunte Culpepper | MIN | QB | 22 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Daunte Culpepper | MIN | QB | 184 | |
| Jeff Garcia | SF | QB | 176 | |
| Donovan McNabb | PHI | QB | 163 | |
| Peyton Manning | IND | QB | 158 | |
| Curtis Martin | NYJ | RB | 157 | |
| Aaron Brooks | NO | QB | 141 | |
| Brian Griese | DEN | QB | 141 | |
| Rod Smith | DEN | WR | 141 | |
| Brett Favre | GB | QB | 138 | |
| Kurt Warner | STL | QB | 137 |