| Week | Player | Team | Pos | Pts |
| Antowain Smith | BUF | RB | 27 | |
| Steve McNair | TEN | QB | 26 | |
| Ahman Green | GB | RB | 26 | |
| Dominic Rhodes | IND | RB | 26 | |
| Tim Brown | OAK | WR | 23 | |
| Garrison Hearst | SF | RB | 22 | |
| Tiki Barber | NYG | RB | 22 | |
| Aaron Brooks | NO | QB | 21 | |
| Doug Flutie | SD | QB | 21 | |
| Rich Gannon | OAK | QB | 20 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Daunte Culpepper | MIN | QB | 222 | |
| Jeff Garcia | SF | QB | 212 | |
| Aaron Brooks | NO | QB | 188 | |
| Peyton Manning | IND | QB | 186 | |
| Rich Gannon | OAK | QB | 181 | |
| Donovan McNabb | PHI | QB | 181 | |
| Kurt Warner | STL | QB | 177 | |
| Brett Favre | GB | QB | 169 | |
| Terrell Owens | SF | WR | 166 | |
| Steve McNair | TEN | QB | 163 |