| Week | Player | Team | Pos | Pts |
| Marshall Faulk | STL | RB | 37 | |
| Brett Favre | GB | QB | 33 | |
| Kurt Warner | STL | QB | 29 | |
| Aaron Brooks | NO | QB | 26 | |
| Rich Gannon | OAK | QB | 24 | |
| Donovan McNabb | PHI | QB | 23 | |
| Steve McNair | TEN | QB | 22 | |
| Peyton Manning | IND | QB | 21 | |
| Joe Horn | NO | WR | 21 | |
| Randy Moss | MIN | WR | 20 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Daunte Culpepper | MIN | QB | 229 | |
| Jeff Garcia | SF | QB | 228 | |
| Aaron Brooks | NO | QB | 214 | |
| Peyton Manning | IND | QB | 207 | |
| Kurt Warner | STL | QB | 206 | |
| Rich Gannon | OAK | QB | 205 | |
| Donovan McNabb | PHI | QB | 204 | |
| Brett Favre | GB | QB | 202 | |
| Marshall Faulk | STL | RB | 190 | |
| Steve McNair | TEN | QB | 185 |