| Week | Player | Team | Pos | Pts |
| Priest Holmes | KC | RB | 38 | |
| Steve McNair | TEN | QB | 23 | |
| Michael Bennett | MIN | RB | 23 | |
| Ahman Green | GB | RB | 22 | |
| Doug Flutie | SD | QB | 22 | |
| Kurt Warner | STL | QB | 21 | |
| Marshall Faulk | STL | RB | 21 | |
| Randy Moss | MIN | WR | 21 | |
| Travis Henry | BUF | RB | 21 | |
| Rich Gannon | OAK | QB | 20 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Jeff Garcia | SF | QB | 238 | |
| Aaron Brooks | NO | QB | 231 | |
| Daunte Culpepper | MIN | QB | 229 | |
| Kurt Warner | STL | QB | 227 | |
| Rich Gannon | OAK | QB | 225 | |
| Donovan McNabb | PHI | QB | 224 | |
| Brett Favre | GB | QB | 215 | |
| Marshall Faulk | STL | RB | 211 | |
| Peyton Manning | IND | QB | 209 | |
| Steve McNair | TEN | QB | 208 |