| Week | Player | Team | Pos | Pts |
| Dominic Rhodes | IND | RB | 30 | |
| Kurt Warner | STL | QB | 28 | |
| Randy Moss | MIN | WR | 26 | |
| Isaac Bruce | STL | WR | 26 | |
| Peyton Manning | IND | QB | 26 | |
| Corey Dillon | CIN | RB | 23 | |
| Anthony Thomas | CHI | RB | 23 | |
| Steve McNair | TEN | QB | 21 | |
| Aaron Brooks | NO | QB | 19 | |
| Ricky Watters | SEA | RB | 19 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Kurt Warner | STL | QB | 255 | |
| Aaron Brooks | NO | QB | 250 | |
| Jeff Garcia | SF | QB | 247 | |
| Rich Gannon | OAK | QB | 240 | |
| Donovan McNabb | PHI | QB | 237 | |
| Peyton Manning | IND | QB | 235 | |
| Brett Favre | GB | QB | 233 | |
| Steve McNair | TEN | QB | 229 | |
| Daunte Culpepper | MIN | QB | 229 | |
| Marshall Faulk | STL | RB | 227 |