| Week | Player | Team | Pos | Pts |
| Edgerrin James | IND | RB | 37 | |
| Ricky Watters | SEA | RB | 34 | |
| Jimmy Smith | JAX | WR | 28 | |
| Mark Brunell | JAX | QB | 25 | |
| James Stewart | JAX | RB | 25 | |
| Stephen Davis | WAS | RB | 24 | |
| Ricky Williams | NO | RB | 23 | |
| Saint Louis | STL | ST/D | 22 | |
| Marcus Robinson | CHI | WR | 22 | |
| Peyton Manning | IND | QB | 21 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Peyton Manning | IND | QB | 202 | |
| Stephen Davis | WAS | RB | 198 | |
| Kurt Warner | STL | QB | 196 | |
| Edgerrin James | IND | RB | 188 | |
| Marvin Harrison | IND | WR | 176 | |
| Brad Johnson | WAS | QB | 173 | |
| Doug Flutie | BUF | QB | 172 | |
| Marshall Faulk | STL | RB | 159 | |
| Drew Bledsoe | NE | QB | 158 | |
| Emmitt Smith | DAL | RB | 152 |