| Week | Player | Team | Pos | Pts |
| Jerry Rice | SF | WR | 27 | |
| Corey Dillon | CIN | RB | 26 | |
| Edgerrin James | IND | RB | 25 | |
| Dan Marino | MIA | QB | 24 | |
| Kurt Warner | STL | QB | 23 | |
| Carl Pickens | CIN | WR | 22 | |
| Charlie Garner | SF | RB | 20 | |
| James Stewart | JAX | RB | 20 | |
| Mark Brunell | JAX | QB | 19 | |
| Tim Brown | OAK | WR | 19 | |
 | ||||
| Season | Player | Team | Pos | Pts |
| Kurt Warner | STL | QB | 235 | |
| Peyton Manning | IND | QB | 226 | |
| Edgerrin James | IND | RB | 225 | |
| Stephen Davis | WAS | RB | 215 | |
| Marshall Faulk | STL | RB | 202 | |
| Brad Johnson | WAS | QB | 198 | |
| Marvin Harrison | IND | WR | 193 | |
| Doug Flutie | BUF | QB | 188 | |
| Rich Gannon | OAK | QB | 185 | |
| Eddie George | TEN | RB | 182 |